What to Do When Zofran Doesn't Work

February 15, 2024

Zofran, or ondansetron, helps control nausea and vomiting in cancer patients undergoing chemotherapy and radiation therapy. It is also a common medication for morning sickness in pregnant women. However, some people may not respond to this drug, and others may experience side effects. This article discusses what to do when zofran doesn’t work, and other options for those who need it.

This medicine is in a class of medications called 5-HT3 receptor antagonists. It works by blocking the action of serotonin in the brain to prevent nausea and vomiting caused by cancer chemotherapy, radiotherapy, or surgery. This medicine may be given with or without food. It should not be given to children younger than 4 years of age. The liquid version (oral solution or Zofran ODT) is usually given directly into the mouth, but it can also be swallowed with a spoon. For children who cannot swallow pills, a specially designed tablet, Zofran ODT (oral disintegrating tablets) is available. This tablet should be placed on the tongue and allowed to dissolve. It should not be chewed or crushed. It is important to tell your doctor or nurse practitioner before you take this medicine if you are taking other prescription drugs, herbs, or vitamins; or if you have liver disease, a history of long QT syndrome, or any other medical conditions. This medication contains phenylalanine and should not be taken by people who have phenylketonuria.

Some of the most common side effects of Zofran are headache, dizziness, tiredness, and itching. Rarely, it can cause a fast heart rate, mental status changes such as agitation, hallucinations, or coma; or a problem with the blood vessels or heart rhythm (especially at higher doses).

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