The lowest temperature a human can survive outside is going to depend on a lot of factors, like air and body temperature, water saturation, and how long you’re exposed to freezing temperatures. Getting wet, for example, makes things much worse since your body loses heat 25 times faster in water than in air. It can also take just a few minutes for frost bite to set in at sub-zero temperatures, especially when you add wind chill into the mix.

As Live Science explains, your normal core body temperature is around 98.6 degrees Fahrenheit. If it drops below that, you start to experience hypothermia, which interferes with your brain and heart’s ability to function normally. If you drop to 82 degrees Fahrenheit, you’ll begin experiencing mild hypothermia, which might cause you to forget or become confused. If you fall to 81 degrees, you’ll start losing consciousness and you’re in danger of dying from hypothermia.

You might be able to get away with being in super cold temperatures for short periods of time, but only if you’re properly dressed and insulated. Clothing layers that trap air are important, as is wearing a hat and wool gloves. Avoiding any moisture inside your clothes is another big thing—especially if you’re sweating, which will further speed up the loss of heat.

Everyone is susceptible to cold temperatures, but the elderly and people on certain medications are particularly at risk. This is because they can’t regulate their temperature as well as younger adults, and some medications can interfere with your body’s natural ability to sweat.